Well, that title definitely sounds like a marketing introduction but I swear, I have no affiliation with Xero apart from thinking that they have some of the best SME accounting software that I've come across.
Being web-based, getting transaction feeds directly from banks, having multi-currency support, simple expense claims, fixed-asset register and most importantly, an API for developers; Xero is highly integrated and, most importantly (and rarely), is actually fun to use.
For the last week or so I have been hacking away at the Ruby xero_gateway library project started by Tim Connor and have been having quite a lot of fun. It's great to take a break from customer-facing software for a while and developing code that will be used by other developers.
If you want to check out Xero, head on over to their main site or their developer's site.
Now, shameless plug, if you are an SME and looking to get some extra efficiency by integrating your current business processes/software with your accounting package, give me a shout and I'm sure to be able to help you get more (time/information/money) from less.